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Graduate Course Proposal Form Submission Detail - GMS6448
Tracking Number - 4847

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Current Status: Approved by SCNS - 2014-04-01
Campus: Tampa
Submission Type: New
Course Change Information (for course changes only):
Comments: for MNM conc in MSMS; to Chair; pending confirmation of which course it replaces; Apprd 12/10/13To USF Sys 2/4/14, to SCNS 2/12/14. Approved eff 4/1/14

Detail Information

  1. Date & Time Submitted: 2013-11-13
  2. Department: Medical Sciences
  3. College: MD
  4. Budget Account Number: 610601
  5. Contact Person: Michael J. Barber
  6. Phone: 9749908
  7. Email:
  8. Prefix: GMS
  9. Number: 6448
  10. Full Title: Advanced Endocrine Therapies
  11. Credit Hours: 3
  12. Section Type: C - Class Lecture (Primarily)
  13. Is the course title variable?: N
  14. Is a permit required for registration?: Y
  15. Are the credit hours variable?: N
  16. Is this course repeatable?: Y
  17. If repeatable, how many times?: 1
  18. Abbreviated Title (30 characters maximum): Advanced Endocrine Therapies
  19. Course Online?: C - Face-to-face (0% online)
  20. Percentage Online: 0
  21. Grading Option: -
  22. Prerequisites: None
  23. Corequisites: None
  24. Course Description: The course is designed to provide advanced discussion of female endocrinology and focuses on topics including estrogen metabolism, breast cancer and advanced therapies in dysmenorrhea, vulvodynia, cervical dysplasia, endometriosis, fibrocystic disease.

  25. Please briefly explain why it is necessary and/or desirable to add this course: Replacing Selected Topics with Permanent number; already listed in program
  26. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service? Metabolic Nutritional Medicine represents a new and evolving discipline in the medical sciences that deals with an integrative and functional medicine approach to healthcare and disease prevention The discipline combines evidence based medicine with new approaches to therapeutics and patient wellness. Advanced Endocrine Therapies represents a critical approach to understanding and controlling hormonal-linked diseases such as obesity, prostatitis, menopause, andropause, ED and cancer. The Metabolic Nutritional Medicine concentration currently has 131 registered students and approx 25 registered for the first course offering.
  27. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times? Yes, 1 time
  28. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.) All the instructors in the course are M.D., D.O. or Ph.D. or equivalent trained faculty.
  29. Objectives: The course objectives include:

    Identifying the major female endocrine diseases

    Comparing and contrasting the value of specific biomarkers in endocrine disease diagnosis

    Discussion of female hormone biosynthesis

    Discussion of estrogen metabolism

    Discussion of risk factors and treatment of breast health and breast cancer

    Discussion of the relationship between hormone levels and memory function

    Examination of the relationship between hormone levels and heart health Extensive discussion of difficult women's issues that including advanced therapies in dysmenorrhea, vulvodynia, cervical dysplasia, endometriosis, fibrocystic breast disease, dysfunctional uterine bleeding and amenorrhea

    Discussion of hormone replacement therapy

    Identification of various environmental toxins and their effects on endocrine function

    Comparing and contrasting the various vitamin and mineral supplements used in endocrine therapies

    Comparing and contrasting the various botanical supplements used in endocrine therapies

  30. Learning Outcomes: At the completion of this course, the students will be able to:

    • Examine the emerging paradigm of neuroendocrineimmune testing

    • Discuss the role of neurotransmitters, hormones, and cytokines as chemical mediators of one interconnected supersystem

    • Describe the utility of biomarker assessments to guide treatment decisions

    • Discuss salivary cortisol, DHEA, hormone testing and its relationship to neurotransmitter levels and behavioral manifestations

    • Understanding the role of inflammation and root cause etiology

    • Examine case studies and clinical applications and the order of treatment protocols

    • Discuss considerations and understanding in converting psychotropic medications to targeted amino acid precursor treatment

    • Prevent and reducing addictive behaviors through the applications of balancing the neuroendocrineimmune system

    • Examine case studies in the overlap of multidisciplinary approaches for the collaboration of treatment and optimal patient outcomes

    • Review the literature on general biochemical pathways of estrogen synthesis, metabolism, and elimination

    • Discuss estrogen metabolites and the link to breast cancer

    • Present clinical studies that support and refute the role of specific estrogen metabolites and breast cancer risk

    • Discuss methods and types of body fluids and tissues used to detect estrogen metabolites

    • Assess the utility of estrogen metabolite testing in urine of women pre- and post-estrogen replacement therapy

    • Provide information on dietary, nutritional, and lifestyle modifications to lower formation of potentially dangerous estrogen metabolites that may increase breast cancer risk

    • Discuss a rational, gradual approach to initiating BHRT

    • Examine tools for managing the issue of breast pain

    • Learn strategies for identifying the cause of abnormal bleeding

    • Understand the relationship between thyroid and estrogen

    • Discuss strategies for reducing breast cancer risk

    • Learn the demographics associated with memory loss

    • Learn the role that toxic metal exposure plays in cognitive decline

    • Examine the position alcohol may play in memory loss

    • Review the importance of hormonal balance in brain fitness

    • Understand the role that some medications may play in cognitive decline

    • Learn the effect closed head injuries may have on memory • Examine the possible function that fluoride may have as an etiology of cognitive decline

    • Learn the kinds of degenerative dementia

    • Understand cognitive reserve

    • Know which labs and other studies to order in the evaluation of a patient for memory loss

    • Learn the prevalence of vitamin D deficiency in the general population

    • Understand the diverse biological actions of vitamin D and discover the role of vitamin D receptors

    • Review the medical literature related to the transcriptional activity of vitamin D

    • Learn that low vitamin D levels have been associated with an increased risk in cancer development

    • Learn the mechanisms of the anticancer effects of calcitriol as related to growth arrest and differentiation, apoptosis, inhibition of invasion and metastasis, anti-inflammatory effects, regulation of prostaglandin metabolism and signaling, induction of mitogen-activated protein kinase phosphatase-5 and inhibition of stress-related kinase signaling, inhibition of NFkB activation and signaling, and inhibition of angiogenesis

    • Discuss a variety of mechanisms that toxins can affect endocrine function

    • Explore methods of laboratory testing for toxic effects to the endocrine system

    • Explain the role that toxic exposure may play in the development of thyroid disorders

    • Understand the role that toxic exposure may play in the development of adrenal function

    • Explain the role that toxic exposure may play in the development of diabetes

    • Explore the role that toxic exposure may play in the development disorders of calcium and bone

    • metabolism

    • Evaluate the role that toxic exposure may play in the development of pituitary gland disorders

    • Identify toxins that are endocrine disrupters

    • Discuss new treatments for bacterial vaginosis

    • Discuss new treatment modalities for cervical dysplasia

    • Identify new therapies for chloasma

    • Discover the risk factors, causes, symptoms, and treatments for endometriosis

    • Discuss new therapies to treat fibrocystic breast disease

    • Discuss the psychological changes that are causes and contributors to menstrual migraines

    • Identify new treatments for menstrual migraines

    • Examine new knowledge concerning premenstrual dysphoric disorder

    • Discuss new treatments for dysmenorrhea

    • Examine knowledge concerning premature ovarian decline and premature ovarian failure and with new treatments

  31. Major Topics: Major course topics include:

    Hormones & Memory

    Hormones & the cardiovascular System

    Vitamin D: Cancer Prevention & Treatment

    Fibrocystic Breast Disease & Breast Pain

    Hot Flashes & Night Sweats: A New Approach

    Vaginal Dryness

    Dysfunctional Uterine Bleeding


    Case Studies


    A Metabolic Approach to Fibroids



    Female BHRT: Case Studies & Mechanism

    Estrogen Metabolism & Breast Cancer Risk

    Cervical Dysplasia

    A Metabolic Approach to Vaginal Infections

    Endocrine Disrupting Chemicals

  32. Textbooks: Romm, A., “Botanical Medicine for Women’s Health.” Churchill Livingstone, 2010.

    Greenspan, F.S. & Gardner, D.G., “Basic and Clinical Endocrinology”, 8th Ed. McGraw-Hill Prof. Publ., 2007.

    Morley, J.E. & van den Berg, L. eds., “Endocrinology of Aging”. Humana Press, 1999.

  33. Course Readings, Online Resources, and Other Purchases: Additional and appropriate readings will be identified and posted on Canvas.
  34. Student Expectations/Requirements and Grading Policy: The course requires the completion of 3 case study research papers 15% each 45% of grade. Comprehensive midterm exam 23% of grade. Comprehensive final exam 23% of grade. 5 webcasts 9% of grade.
  35. Assignments, Exams and Tests: The course requires completion of 4 unit self-assessment quizzes, 3 case studies research papers, a comprehensive midterm exam, a comprehensive final exam and 5 webcasts.
  36. Attendance Policy: Course Attendance at First Class Meeting – Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation – Registration - 4.0101,

    Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (

    In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. It’s the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.

  37. Policy on Make-up Work: For documented student absences, such as for illness, students will be allowed to make up any missing case reports or exams. Students will be required to abide by USF policy on academic integrity as described in course syllabus.
  38. Program This Course Supports: MS MS Metabolic & Nutritional Medicine concentration & GC Advanced Endocrinology
  39. Course Concurrence Information: Program This Course Supports

    MS MS Metabolic & Nutritional Medicine concentration & GC Advanced Endocrinology

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