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Graduate Course Proposal Form Submission Detail - GMS6410

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Current Status: -
Campus: Tampa
Submission Type: Change
Course Change Information (for course changes only): This application is being submitted to reinstate a course that was accidentally deleted from the catalog.

  1. Department and Contact Information

    Tracking Number Date & Time Submitted
    4788 2013-07-29
    Department College Budget Account Number
    Medical Sciences MD
    Contact Person Phone Email
    Jerome Breslin, Ph.D. 8139747631

  2. Course Information

    Prefix Number Full Title
    GMS 6410 Cardiovascular Regulation

    Is the course title variable? N
    Is a permit required for registration? Y
    Are the credit hours variable? N
    Is this course repeatable?
    If repeatable, how many times? 0

    Credit Hours Section Type Grading Option
    4 C - Class Lecture (Primarily) -
    Abbreviated Title (30 characters maximum)
    Cardiovascular Regulation
    Course Online? Percentage Online
    C - Face-to-face (0% online) 0


    GMS 6001, GMS 6440, GMS 6505


    Course Description

    The course involves discussions/advanced readings of current trends in many aspects of the cardiovascular system including cardiac function, vascular biology, and signaling.

  3. Justification

    A. Please briefly explain why it is necessary and/or desirable to add this course.

    B. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service?

    This is not a new course. It was accidentally terminated when its number was assigned to a new cardiovascular course for another program by the university. 5-6 PhD students who wish to concentrate their studies in Cardiovascular Biology will need to take this course in the fall to stay on track toward their degrees. The course is required for completion of the PhD in Medical Sciences with a concentration in Cardiovascular Biology.

    C. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times?

    Yes, 3 or more times

    D. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.)

    Doctoral degree, active clinician or laboratory researcher with expertise in cardiology or cardiovascular sciences.

  4. Other Course Information

    A. Objectives

    Cardiovascular Regulation (GMS 6410, 4 Cr. Hrs.) is designed for advanced Graduate students with interests in the regulation and function of the cardiovascular system. Students admitted to this course will have successfully completed 1st year Graduate-level coursework in the Biomedical Sciences Ph.D. or M.S. program. The course will involve in-depth discussions of current topics in cardiovascular research that include the heart, blood vessels, and kidneys. Students will also critically evaluate assigned primary research articles covering each topic area in a “Journal Club” format.

    The course emphasizes key research findings that have led to the development of modern theories and concepts in cardiovascular science, with emphasis on cutting-edge findings that are currently challenging existing paradigms and changing the field. After successfully completing this course, students will be able to:

    (1) Describe the basic observations and experimental approaches that have served as a foundation for current understanding of cardiovascular physiology.

    (2) Critically evaluate scientific literature about molecular mechanisms that control cardiovascular function.

    (3) Perform self-directed study of scientific literature and form a hypothesis about a current research problem in cardiovascular regulation.

    (4) Present and defend a research proposal in cardiovascular regulation.

    B. Learning Outcomes

    This course is designed to provide cutting-edge scientific material to the students, while also help them develop the ability to critically review research literature, form a hypothesis, and design a study to study a current research question in the cardiovascular field. Specific learning objectives are to:

    (1) Understand the significance of current cardiovascular research topics

    (2) Become aware of new experimental techniques and evidence that is changing cardiovascular research.

    (3) Develop skills in critical evaluation of scientific literature in the cardiovascular field

    (4) Develop skills to research cardiovascular literature independently.

    (5) Develop knowledge and skills to write a research proposal about a relevant cardiovascular research topic.

    (6) Acquire sufficient knowledge to discuss and defend a research proposal with other cardiovascular researchers.

    C. Major Topics

    Cardiac function, vascular function, blood pressure, autonomics, renin-angiotensin-aldosterone system, ion channels, endothelium, vascular smooth muscle, microcirculation, lymphatic vessels

    D. Textbooks


    E. Course Readings, Online Resources, and Other Purchases

    Recent journal articles for class discussion will be assigned each week by the instructors.

    F. Student Expectations/Requirements and Grading Policy

    There will be a series of two-hour presentation and group discussion sessions throughout the semester. Every Thursday, a student will present the journal article assigned for the class, and the class will discuss the study design, experimental data, and conclusions. Presentation and participation in these sessions will contribute to 50% of the final course grade.

    Each student will also pick a research topic relevant to the course, read the current literature on the topic, develop a hypothesis and basic research plan, and write a “Specific Aims” page describing the proposed hypothesis and research plan. Each student will give an oral presentation to the class, describing and defending their proposals (30-45 min., depending on class size). The topic should be picked and approved by the course director by September 30. A draft of the “Specific Aims” page will be due October 14, and the final draft will be due November 22. The oral presentations will be on December 3 and 5. The written and oral portions of this assignment will each contribute 25% toward the final course grade.

    G. Assignments, Exams and Tests

    Topics include:

    Control of blood pressure during hemorrhagic shock

    Student critique and discussion of assigned journal article

    Mechanisms controlling intracellular calcium changes in cardiomyocytes

    Student critique and discussion of assigned journal article

    Regulation of Na reabsorption in pressure natriuresis

    Student critique and discussion of assigned journal article

    Ion channels in vascular smooth muscle and endothelial cells

    Student critique and discussion of assigned journal article

    Local autonomic circuits regulating heart function

    Student critique and discussion of assigned journal article

    Renin-angiotensin-aldosterone system signaling

    Student critique and discussion of assigned journal article

    Ischemic regulation of cerebral blood vessels and the blood-brain barrier

    Student critique and discussion of assigned journal article

    Nociception, reflexes, and cardiovascular function

    Student critique and discussion of assigned journal article

    Micro RNAs in the control of cardiovascular function

    Student critique and discussion of assigned journal article

    Control of lymphatic vessel function

    Student critique and discussion of assigned journal article

    Signal transduction controlling microvascular permeability

    Student critique and discussion of assigned journal article

    Regulation of endothelial cell shape by adhesion and cytoskeletal dynamics

    Student critique and discussion of assigned journal article

    Regulation of microvascular function by growth factors and matrix

    Student critique and discussion of assigned journal article

    Oral Presentations by Students

    H. Attendance Policy

    Course Attendance at First Class Meeting – Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation – Registration - 4.0101,

    Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (

    In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. It’s the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.

    I. Policy on Make-up Work

    Modifications to the class agenda and/or make-up work will be permitted in the event of a University closure.

    J. Program This Course Supports

    Ph.D. in Medical Sciences

  5. Course Concurrence Information

    This is a required course for the Cardiovascular Biology concentration in the PhD in Medical Sciences.

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