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Graduate Course Proposal Form Submission Detail - CHM6279

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Current Status: Approved by SCNS - 2014-11-01
Campus: Tampa
Submission Type: New
Course Change Information (for course changes only):
Comments: to GC 4/7/14. Desc too Long; Objectives need revision. Emailed 5/2/14. Revised; Approved 5/19/14; to USF Sys 5/20/14; to SCNS 5/28/14. Appd 11/1/14


  1. Department and Contact Information

    Tracking Number Date & Time Submitted
    4781 2013-07-17
     
    Department College Budget Account Number
    Chemistry AS 121300
     
    Contact Person Phone Email
    James Leahy 8139744642 jwleahy@usf.edu

  2. Course Information

    Prefix Number Full Title
    CHM 6279 Introduction to Drug Discovery

    Is the course title variable? N
    Is a permit required for registration? N
    Are the credit hours variable? N
    Is this course repeatable? N
    If repeatable, how many times? 0

    Credit Hours Section Type Grading Option
    3 C - Class Lecture (Primarily) R - Regular
     
    Abbreviated Title (30 characters maximum)
    Introduction to Drug Discovery
     
    Course Online? Percentage Online
    C - Face-to-face (0% online) 0

    Prerequisites

    BSC 2011, CHM 2211

    Corequisites

    Course Description

    E explores the entire drug discovery process, from initial target identification and hit generation through lead optimization and clinical trials to FDA approval. Case studies will be used to illustrate the process.


  3. Justification

    A. Please briefly explain why it is necessary and/or desirable to add this course.

    Needed to compete with national trends

    B. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service?

    As our graduates attempt to start careers in places like the pharmaceutical industry or biotechnology, they will be better prepared to succeed if they understand what is required to discover and develop a drug. Without a class such as this, they would be at a disadvantage compared to their peers from other universities.

    C. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times?

    Yes, 1 time

    D. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.)

    A Ph.D. or M.D. degree is required to teach this class. In addition, a thorough understanding of organic chemistry, biology and biochemistry. In addition, a working knowledge of the drug discovery and development process would be ideal.


  4. Other Course Information

    A. Objectives

    The objectives of this course are:

    1) To provide a detailed overview of the drug discovery process;

    2) To introduce the fundamentals required to understand and evaluate assays for activity, pharmacokinetics and pharmacodynamics;

    3) To reveal several strategies for the simultaneous optimization of all pertinent parameters for drug discovery.

    4) To illustrate various methods for the discovery of a number of drugs through several case studies, including challenges faced in taking potential drug candidates from discovery through the FDA approval process.

    B. Learning Outcomes

    Upon completion of this class, students will:

    1) have a thorough understanding of the entire drug discovery process;

    2) be able to assess what is necessary to progress a drug candidate past all of the preclinical and clinical hurdles as well as appreciate the time and cost that is typically required to perform these tasks;

    3) fully understand the legal constraints of patents and how to be able to create new drugs without violating intellectual property laws; and

    4) understand the difference between the classes of drugs (small molecules vs. biologics) and the unique challenges associated with the discovery, development and manufacturing of each of these classes.

    C. Major Topics

    Target discovery

    Assay development

    Automation

    High throughput capabilities

    Hit discovery (screening, rational drug design, literature/patent mining)

    Parallel lead optimization

    Pharmacokinetics (Absorption, Distribution, Metabolism, Excretion)

    Models for human toxicity

    Pharmacodynamics

    IND Application

    FDA Clinical Trial phases

    D. Textbooks

    Goodman and Gilman's The Pharmacological Basis of Therapeutics

    An Introduction to Medicinal Chemistry by Graham L. Patrick

    E. Course Readings, Online Resources, and Other Purchases

    Topical literature references will be selected throughout the term to illustrate aspects of the class

    F. Student Expectations/Requirements and Grading Policy

    2 exams (1 midterm, 1 final exam), plus a term paper that will be due the final week of classes

    G. Assignments, Exams and Tests

    H. Attendance Policy

    Course Attendance at First Class Meeting Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation Registration - 4.0101,

    http://usfweb2.usf.edu/usfgc/ogc%20web/currentreg.htm)

    Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (http://usfweb2.usf.edu/usfgc/gc_pp/acadaf/gc10-045.htm)

    In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. Its the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.

    I. Policy on Make-up Work

    J. Program This Course Supports

    Chemistry


  5. Course Concurrence Information

    Students in CMMB, Global Health and the College of Pharmacy would theoretically be interested in this class. I can envision students in the Department of Molecular Medicine being interested as well.



- if you have questions about any of these fields, please contact chinescobb@grad.usf.edu or joe@grad.usf.edu.