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Graduate Course Proposal Form Submission Detail - GMS6056
Tracking Number - 3131

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Current Status: Approved by SCNS - 2014-11-01
Campus: Tampa
Submission Type: New
Course Change Information (for course changes only):
Comments: to GC 5/6/13 for MSMS Program. Approved. Cleared Syst Concurrence 7/31/13. to SCNS 8/5/13. Discont. 2008 - reinstate or new? Pending faculty response. Appd eff 11/1/14

Detail Information

  1. Date & Time Submitted: 2013-03-16
  2. Department: Deans Office
  3. College: MD
  4. Budget Account Number: 6108-000
  5. Contact Person: Michael J. Barber, D.Phil.
  6. Phone: 8139749908
  7. Email:
  8. Prefix: GMS
  9. Number: 6056
  10. Full Title: Targeted Cancer Therapies
  11. Credit Hours: 3
  12. Section Type: C - Class Lecture (Primarily)
  13. Is the course title variable?: N
  14. Is a permit required for registration?: Y
  15. Are the credit hours variable?: N
  16. Is this course repeatable?:
  17. If repeatable, how many times?: 0
  18. Abbreviated Title (30 characters maximum): Targeted Cancer Therapies
  19. Course Online?: C - Face-to-face (0% online)
  20. Percentage Online: 0
  21. Grading Option: R - Regular
  22. Prerequisites: None
  23. Corequisites: None
  24. Course Description: This course is designed to focus on exploring targeted cancer therapies for a variety of specific forms of cancer together with the application of novel therapeutic regimes.

  25. Please briefly explain why it is necessary and/or desirable to add this course: Replacing Selected Topics with Permanent number; already listed in program
  26. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service? Metabolic Nutritional Medicine represents a new and evolving discipline in the medical sciences that deals with an integrative and functional medicine approach to healthcare and disease prevention The discipline combines evidence based medicine with new approaches to therapeutics and patient wellness. Nutrition and metabolism represent a critical approaches to understanding and controlling obesity The Metabolic Nutritional Medicine concentration currently has 110 registered students and approx 10 registered for the first course offering.
  27. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times? Yes, 1 time
  28. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.) All the instructors in the course are M.D., D.O. or Ph.D. or equivalent trained faculty.
  29. Objectives: The course objectives include:

    Discussing and understanding cancer as an "organ-like" disease.

    Examining the history of traditional cancer therapies and their development.

    Comparing and contrasting the effectiveness of traditional cancer therapies including surgery, radiation and chemotherapy.

    Discussing the concept of personalized cancer chemotherapy.

    Discussion of the principles of targeted cancer therapies.

    Comparing and contrasting the physiological properties of the most common targeting receptors active in cancer.

    Identify and discussing the major drugs used as targeting agents in cancer.

    Identifying and discussing which botanical compounds significantly potentiate those cancer drugs that act on specific growth factor receptors and/or signaling pathways such as mTOR, COX-2, HDAC, NF-kB and immune-system.

    Discussing tumor angiogenesis and comparing and contrasting anti-angiogenic agents.

    Comparing and contrasting types of ablation therapies including radiofrequency, heat and cryo.

    Discussing the future potential of ablation therapy and exploring the future of ablation gene therapy.

    Defining gene therapy and comparing and contrasting the objectives of gene therapy.

    Discussing cancer vaccines.

    Comparing and contrasting the results of modern studies of cyanogenic glycosides and cancer.

    Exploring the historical perspectives of the effects of surgery on tumor growth.

    Discussing the two evolutionary principles of cancer.

    Comparing and contrasting glioblastoma therapies such as surgery, radiation and chemotherapy.

  30. Learning Outcomes: At the completion of this course, students will be able to:

    •Explore targeted therapies for acute myelogenous leukemia

    •Explore targeted therapies in breast and other female cancers

    •Explore targeted treatments in chronic lymphocytic leukemia

    •Discuss targeted therapies in chronic myeloid leukemia

    •Discuss targeted therapies in colorectal and other GI cancers

    •Identify targeted therapies in non-small cell lung cancer

    •Comprehend targeted therapies in lymphoma

    •Explore targeted treatment in melanoma

    •Identify targeted therapies in multiple myeloma

    •Discuss targeted treatments for myelodysplastic syndrome

    •Describe targeted therapies in epithelial ovarian cancer

    •Discuss targeted drug therapy in pancreatic cancer

    •Learn targeted therapy in prostate cancer

    •Describe targeted therapy in renal cell carcinoma

    •Explore targeted therapies in sarcoma

    •Examine personalized cancer therapies

    •Compare and contrast head and neck cancer treatments

    •Discuss brain cancer therapies

    •Examine new nanoparticle approaches to cancer

    •Explore genetic tissue testing

    •Discuss the role proteomics has in cancer diagnosis and treatment

  31. Major Topics: Major course topic include:

    Personalizing Cancer Drug Selection

    Cell Signaling Pathways & Targeted Agents

    VEGF and Tumor Angiogenesis

    Advances in Image Guided Cancer Ablation

    Immuno and Gene Therapy

    Laetrile, Amygdalin & Cyanogenic Glycosides

    The Effects of Surgery on Tumor Growth

    Evolutionary Dynamics of Cancer


  32. Textbooks: Paradee, A. & Stein, G., eds.,"The Biology and Treatment of Cancer: Understanding Cancer". John Wiley & Sons, New York, 2009.

    Weinberg, R.A., "The Biology of Cancer". Garland, 2006.

  33. Course Readings, Online Resources, and Other Purchases: Additional and appropriate readings will be identified and posted on Blackboard.
  34. Student Expectations/Requirements and Grading Policy: The course requires the completion of 3 case study research papers 15% each 45% of grade. Comprehensive midterm exam 23% of grade. Comprehensive final exam 23% of grade. 5 webcasts 9% of grade.
  35. Assignments, Exams and Tests: The course requires completion of 4 unit self-assessment quizzes, 3 case studies research papers, a comprehensive midterm exam, a comprehensive final exam and 5 webcasts.
  36. Attendance Policy: Course Attendance at First Class Meeting – Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation – Registration - 4.0101,

    Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (

    In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. It’s the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.

  37. Policy on Make-up Work: For documented student absences, such as for illness, students will be allowed to make up any missing case reports or exams. Students will be required to abide by USF policy on academic integrity as described in course syllabus.
  38. Program This Course Supports: M.S in Medical Sciences- Metabolic & Nutritional Medicine concentration.
  39. Course Concurrence Information: None

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