Graduate Course Proposal Form Submission Detail - PCB6230
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Approved by SCNS
Submission Type: Change
Course Change Information (for course changes only): The primary change is to move selected components to a new course offering (proposed PCB 6205) that will be provided in sequence. Changes will allow enhanced coverage of critical cancer biology topics and will make the program more competitive with national trends in cancer education. Field F - Change abbreviated title to " Basics of Molecular Oncology". The change provides a more informative description and helps distinguish it from other program offerings. Field J Change credit hours to 3 hours to align with the revised material provided over 2 sequential courses. Field Q An introduction to the basics of molecular oncology at the cellular and molecular level. Topics focus on the mechanisms and signals regulating cell growth and death as they relate to cancer. Field R The primary objective of this course is to provide an in-depth understanding of normal and abnormal cell biological processes, molecular signaling pathways, growth control mechanisms, and apoptotic processes as they relate to molecular oncology and cancer biology. Field S Students will understand normal and abnormal cellular processes and acquire fundamental knowledge of signaling transduction, cell cycle control, apoptosis, oncogenes, and tumor suppressors. Field T Topics to be covered include basics of cell transformation, oncogenes, tumor suppressor genes, tumor viruses, signal transduction pathways, extracellular environment and cell invasion, cell cycle control and checkpoints, and apoptosis. Field U Optional Recommended Text: "The Biology of Cancer" by Robert A. Weinberg, 2007. Optional Supplementary Texts: "The Molecular Basis of Cancer" by Mendelsohn, et al. "Molecular Cell Biology" by Lodish, et al. Field W Three exams and no final exam. Exams will be of an essay format, and questions will be derived from the information covered in the lectures and further discussed in the assigned papers. Grades of the three exams will each count for 25% of the final grade. Participation in the analysis of assigned research papers will count for 20% of the final grade. Class attendance will count for the remaining 5% of the final grade. Grades will be based on the following scale: A+: 99-100 points, A: 94-98 points, A-: 90-93 points, B+: 87-89 points, B: 84-86 points, B-: 80-83 points, C+: 77-79 points, C: 74-76 points, C-: 70-73 points, D+: 67-69 points, D+: 64-66 points, D-: 60-63 points, F below 60 points. Field AC Now part of a sequence with a new proposed course. Field AD Major code is CNB.
Comments: to GC Chair 2/5/13 - fro Cancer Bio PhD Change. Revise Obj. Removed 2nd sentence; need more than 1 obj. emailed faculty 2/7/13. updated; GC apprvd 3/4/13. to USF Sys 3/5/13. to SCNS 4/22/13. Apprd eff 6/1/13
- Department and Contact Information
Tracking Number Date & Time Submitted 3057 2013-01-03 Department College Budget Account Number Biology AS 121000 Contact Person Phone Kenneth L. Wright 8137453918 firstname.lastname@example.org
- Course Information
Prefix Number Full Title PCB 6230 Cancer Biology I - Basics of Molecular Oncology Is the course title variable? N Is a permit required for registration? Y Are the credit hours variable? N Is this course repeatable? Y If repeatable, how many times? 1 Credit Hours Section Type Grading Option 4 C - Class Lecture (Primarily) - Abbreviated Title (30 characters maximum) Cancer Biology I Course Online? Percentage Online C - Face-to-face (0% online) 0
An introduction to the basics of molecular oncology. Topics will include cytoplasmic and nuclear oncogenes, cell cycle control, apoptosis, tumor suppressor genes and cancer drug discovery.
A. Please briefly explain why it is necessary and/or desirable to add this course.
Needed to compete with national trends
B. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service?
All Cancer Biology PhD students are required to complete this course. The course provides a necessary foundation in the principles of basic oncology mechanisms.
C. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times?
D. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.)
Experience in cancer biology research and a Ph.D. degree are required.
- Other Course Information
The primary objective of this course is to provide a current understanding of normal and abnormal cellular processes in molecular and cell biology as they relate to cancer. In addition, students will be provided knowledge on the principles of signal transduction, transcriptional regulation, cell cycle control, DNA repair, apoptosis, oncogenes, and tumor suppressors.
B. Learning Outcomes
Students will understand normal and abnormal cellular and molecular biology processes. Students will gain basic knowledge of signaling transduction, transcriptional regulation, cell cycle control, DNA repair, apoptosis, oncogenes, and tumor suppressors.
C. Major Topics
receptor and non-receptor tyrosine kinases, cytoplasmic signaling, steroid receptor signaling, transcriptional regulation, cell cycle control and DNA replication, mitosis and chromosome instability, carcinogenesis, DNA repair, oncogenes, tumor suppressors, apoptosis, integrin signaling, drug discovery.
The Biology of Cancer, 1st Edition. (Weinberg) Garland Science. Molecular Cell Biology 5th Edition. (Lodish, Berk, Matsudaira, Kaiser, Krieger, Scott, Zipursky and Darnell) W.H. Freeman & Co. The Molecular Basis of Cancer, 2nd Edition. (Mendelsohn, Howley, Israel and Liotta) W.B. Saunders. Other books that might be useful: Genes, 6th or 7th Edition (Lewin). Oxford University Press. Molecular Biology of The Cell, 4th Edition (Alberts, Johnson, Lewis, Raff, Roberts, Walter) Garland. Biochemistry, 5th Edition (Stryer) W.H. Freeman & Co.
E. Course Readings, Online Resources, and Other Purchases
Individual lecturers will provide recent primary research articles, and students will be expected to participate in the analysis of these papers as part of their grade.
F. Student Expectations/Requirements and Grading Policy
There are three exams and no final exam. Exams will be of an essay format, and questions will be provided by individual lecturers that are derived from the information covered in the lecture (and further discussed in the primary assigned book) and/or from the assigned papers. Grades of the three exams will each count for 30% of the final grade. Class attendance and participation will count for the remaining 10% of the final grade. Grades will be based on the following scale: A+: 99-100 points, A: 94-98 points, A-: 90-93 points, B+: 87-89 points, B: 84-86 points, B-: 80-83 points, C+: 77-79 points, C: 74-76 points, C-: 70-73 points, D+: 67-69 points, D+: 64-66 points, D-: 60-63 points, F:
G. Assignments, Exams and Tests
Three exams and additional reading assignments.
H. Attendance Policy
Course Attendance at First Class Meeting Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation Registration - 4.0101,
Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (http://usfweb2.usf.edu/usfgc/gc_pp/acadaf/gc10-045.htm)
In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. Its the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.
I. Policy on Make-up Work
A missed exam can be made with prior course instructor approval. Students will adhere to the University policy to maintain high academic integrity. The policy is available at http://www.grad.usf.edu/policies_Sect7_full.php#integrity.
J. Program This Course Supports
- Course Concurrence Information
Biology - Cellular, Molecular, and Microbiology