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Graduate Course Proposal Form Submission Detail - GMS6054
Tracking Number - 2893

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Current Status: Approved by SCNS - 2012-09-26
Campus: Tampa
Submission Type: New
Course Change Information (for course changes only):
Comments: to GC for review. Apprd by GC 9/4/12. To USF Sys 9/4/12; to SCNS 9/14/12. Approved effective 11/1/12

Detail Information

  1. Date & Time Submitted: 2012-07-05
  2. Department: Deans Office
  3. College: MD
  4. Budget Account Number: 6108-000
  5. Contact Person: Michael J. Barber, D.Phil.
  6. Phone: 9749908
  7. Email:
  8. Prefix: GMS
  9. Number: 6054
  10. Full Title: Cancer Biology
  11. Credit Hours: 3
  12. Section Type: C - Class Lecture (Primarily)
  13. Is the course title variable?: N
  14. Is a permit required for registration?: Y
  15. Are the credit hours variable?: N
  16. Is this course repeatable?:
  17. If repeatable, how many times?: 0
  18. Abbreviated Title (30 characters maximum): Cancer Biology
  19. Course Online?: C - Face-to-face (0% online)
  20. Percentage Online: 0
  21. Grading Option: R - Regular
  22. Prerequisites: None
  23. Corequisites: None
  24. Course Description: Designed to give a broad understanding and discussion of the biology of cancer cells and the changes in cell structure and function leading to malignancy and uncontrolled cell proliferation.

  25. Please briefly explain why it is necessary and/or desirable to add this course: Replacing Selected Topics with Permanent number; already listed in program
  26. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service? Metabolic Nutritional Medicine represents a new and evolving discipline in the medical sciences that deals with an integrative and functional medicine approach to healthcare and disease prevention The discipline combines evidence based medicine with new approaches to therapeutics and patient wellness. Cancer biology represents a critical approaches to understanding the biology of cancer cells and how to treat malignant cells. The Metabolic Nutritional Medicine concentration currently has over 100 registered students and approx 20 registered for the first course offering.
  27. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times? Yes, 1 time
  28. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.) All the instructors in the course are M.D., D.O. or Ph.D. or equivalent trained faculty.
  29. Objectives: The course has the following objectives:

    Discuss the basic aspects of cell biology relevant to cancer.

    Identify factors and pathways involved in cell differentiation and dedifferentiation.

    Compare and contrast various pathways involved in apoptosis.

    Examine the classification of different types of cancer cells.

    Provide extensive discussion of the link between immunology and cancer.

    Review the link bewteen ionizing radiation and cancer. Examine the genetics and genomics of cancer.

    Discuss various methods of cancer detection and treatment. Compare and contrast angiogenesis and mutagenesis.

  30. Learning Outcomes: At the completion of this course, participants will be able to:

    •Discuss normal cell biology

    •Explain apoptosis

    •Discuss cell differentiation and loss of cell differentiation

    •Identify cell cycle deregulation including restriction point, pRb pathway, C-Myc proto-oncogene pathway

    •Discuss gene mutations and their role in oncogenesis

    •Compare and contrast DNA repair mechanisms

    •Identify cancers resulting from defects in repair pathways

    •Explain that cancer cells grow best in an anaerobic environment

    •Discuss new strategies for underlying mechanisms of cancer

    •Explain the genetic basis of cancer

    •Discuss the definition of cancer

    •Discuss the role that ionization and UV radiation places on carcinogenesis

    •Discuss viral carcinogenesis

    •Examine the literature on the epidemiology of cancer

    •Discuss mutations and cell defenses

    •Describe methods for cancer detection and biomarkers

    •Describe the growth characteristics of malignant cells

    •Discuss signal transduction mechanisms

    •Discuss angiogenesis and its relationship in cancer development

    •Explain the biology of tumor metastasis

    •Discuss the molecular genetics of cancer

  31. Major Topics: Course topics include:

    Understanding Fever

    Differentiation & Dedifferentiation – An Unresolved Problem

    Cell Biology, Normal & Malignant

    Molecular Biology & the Genetics of Cancer

    Tumor Angiogenesis

    Pathophysiology of Cancer

    Role of Cancer Genetics in Diagnosis & Therapy

    Therapeutic Cancer Vaccines

    Tumor Metastasis

    Principles of Cancer Immunology & Immunotherapy

    Epidemiology of Cancer

    Impact of Integrative Medicine on Cancer

    Plasmacytoid Dendritic Cells

    Ionizing Radiation

    Biology of Natural Killer Cells

  32. Textbooks: The course features two suggested textbooks that provides expert coverage of the course material:

    Paradee, A. & Stein, G., eds.,"The Biology and Treatment of Cancer: Understanding Cancer". John Wiley & Sons, New York, 2009.

    Weinberg, R.A., "The Biology of Cancer". Garland, 2006.

  33. Course Readings, Online Resources, and Other Purchases: Additional and appropriate readings will be identified and posted on Blackboard.
  34. Student Expectations/Requirements and Grading Policy: The course requires the completion of 3 case studies research papers 15% each 45% of grade. Comprehensive midterm exam 23% of grade. Comprehensive final exam 23% of grade. 5 webcasts 9% of grade.
  35. Assignments, Exams and Tests: The course requires completion of 4 unit self-assessment quizzes, 3 case studies research papers, a comprehensive midterm exam, a comprehensive final exam and 5 webcasts.
  36. Attendance Policy: Course Attendance at First Class Meeting – Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation – Registration - 4.0101,

    Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (

    In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. It’s the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.

  37. Policy on Make-up Work: For documented student absences such as for illness students will be allowed to make up any missing case reports or exams Students will be required to abide by USF policy on academic integrity as described in course syllabus.
  38. Program This Course Supports: M.S in Medical Sciences- Metabolic & Nutritional Medicine concentration
  39. Course Concurrence Information: None

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