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Graduate Course Proposal Form Submission Detail - GMS6331
Tracking Number - 2608

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Current Status: Approved by SCNS - 2012-04-09
Campus: Tampa
Submission Type: New
Course Change Information (for course changes only):
Comments: GC review 11/28/11. Need catalog copy. Emailed 11/28/11. for Metabolic Conc in MSMS. GC appd. 1/23/12. to USf Sys 1/24/12. to SCNS 2/1/12; appd eff 4/15/12

Detail Information

  1. Date & Time Submitted: 2011-09-06
  2. Department: Deans Office
  3. College: MD
  4. Budget Account Number: 6108
  5. Contact Person: Michael J. Barber, D.Phil.
  6. Phone: 813 974 9908
  7. Email:
  8. Prefix: GMS
  9. Number: 6331
  10. Full Title: Stem Cell Biology
  11. Credit Hours: 1-3
  12. Section Type: C - Class Lecture (Primarily)
  13. Is the course title variable?: N
  14. Is a permit required for registration?: Y
  15. Are the credit hours variable?: Y
  16. Is this course repeatable?:
  17. If repeatable, how many times?: 0
  18. Abbreviated Title (30 characters maximum): Stem Cell Biology
  19. Course Online?: B - Face-to-face and online (separate sections)
  20. Percentage Online: 0
  21. Grading Option: R - Regular
  22. Prerequisites: None
  23. Corequisites: None
  24. Course Description: Designed to give a broad understanding of the biology of stem cells and their potential role in the treatment of various pathological conditions.

  25. Please briefly explain why it is necessary and/or desirable to add this course: Replacing Selected Topics with Permanent number; already listed in program
  26. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service? This course is offered as an elective for the Metabolic & Nutritional Medicine concentration in the Medical Sciences masters and would serve approximately 25-30 students per year.
  27. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times?
  28. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.) All the faculty involved with the course are experienced lecturers with either M.D. or Ph.D. degrees, or both.
  29. Objectives: The objectives of this course include:

    Develop an understanding of the fundamental biology of stem cells

    Understand the differences between stem cells and other types of mammalian cells

    Discuss various methods of stem cell isolation

    Comparison of the different types of stems cells

    Discuss of the immunology of stem cells

    Compare and contrast the various potential therapeutic applications of stem cells

    Discuss selected case studies on the application of stem cells.

  30. Learning Outcomes: At the completion of this course, the students will be able to:

    • Discuss the basic biology of stem cells

    • Discuss the development of embryonic stem cells and germ cells

    • Compare and contrast the various differentiated stem cell types derived from the ectoderm (neuroprogenitors), mesoderm (cardiomyocytes, hematopoietic progenitors, leucocytes and endothelial cells) and the endoderm (insulin positive cells, hepatocyte-like cells)

    • Explain the principle properties of stem cells including self-renewal, differentiation, totipotency, pluripotency, multipotency, committed progenitors, terminal differentiation and stem cell plasticity or transdifferentiation

    • Discuss the concepts of stem cell niches in bone marrow and vascular tissues

    • Discuss stem cell niches in other organs, including neural, cardiac and skeletal tissues

    • Explain trafficking of stem cells, mobilization of stem cells and the phenotypic differentiation of stem cells

    • Discuss the properties of adult stem cells

    • Compare and contrast the sources of stem cells for autologous cell transplantation and allogeneic cell transplantation

    • Discuss issues of immune compatibility and regeneration of tissues

    • Explain the development of new cellular therapies

    • Discuss the current principles of regenerative medicine and future perspectives

    • Discuss the fundamentals of cell-based therapies, including the rationale of cell-based therapies

    • Compare and contrast autologous cell based therapies and allogeneic cell therapies

    • Discuss the immunosuppressive properties of mesenchymal stem cells

    • Describe the commercialization of cell therapy

    • Identify current issues in stem-cell based therapies

    • Compare and contrast the various cell therapy applications for neural, cardiovascular, orthopedic, metabolic and secretary, hematopoietic and autoimmune functions

  31. Major Topics: Major course topics include:

    Introduction to Stem Cells

    Understanding the Principles of Properties of Stem Cells

    Embryonic Stem Cells/Pluripotent Cell Biology

    Induced Pluripotent Stem Cells

    Pluripotent Cells and Cell Therapies

    Understanding the Concepts of Stem Cell Niches

    Understanding the Concepts of Stem Cell Trafficking and Mobilization

    Adult Stem Cells

    Immunology of Stem Cell transplantation

    Embryonic vs Adult Stem Cells in Therapy

    Stem Cells – Regeneration of Tissues

    Stem Cells and Aging

    Development of New Cellular Therapies

    Clinical Trials in Stem Cell Transplantation

    Current/Future Perspectives

    Rationale – Autologous Stem Cell Transplants

    Rationale – Allogenic Stem Cell Transplantation

    Current Issues in Stem Cell Based Therapies

    Basics of Cell Therapy Applications for Neurological Disorders

    Basics of Cell Therapy Applications for Cardiovascular Disorders

    Basics of Cell Therapy Applications for Bone Disorders

    Basics of Cell Therapy Applications for Metabolic Disorders

    Basics of Cell Therapy Applications for Autoimmune Disorders

  32. Textbooks: Lanza, R. (ed.), “Essentials of Stem Cell Biology”. 2nd Ed., Academic Press, 2009.

    ISBN-13: 978-0123747297.

  33. Course Readings, Online Resources, and Other Purchases: Additional and appropriate readings will be identified and posted on Blackboard.
  34. Student Expectations/Requirements and Grading Policy: 3 case studies or reports (research papers) 15% each, 45% of grade Comprehensive midterm exam 23% of grade Comprehensive final exam 23% of grade 5 webcasts 9% of grade.
  35. Assignments, Exams and Tests: The course requires completion of: 4 unit quizzes (self-assessment) 3 case studies or reports (research papers) Comprehensive midterm exam Comprehensive final exam 5 webcasts.
  36. Attendance Policy: Course Attendance at First Class Meeting – Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation – Registration - 4.0101,

    Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (

    In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. It’s the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.

  37. Policy on Make-up Work: For documented student absences, such as for illness, students will be allowed to make up any missing case reports or exams. Students will be required to abide by USF policy on academic integrity as described in course syllabus.
  38. Program This Course Supports: M.S. in Medical Sciences: Metabolic & Nutritional Medicine concentration
  39. Course Concurrence Information: None

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