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Graduate Course Proposal Form Submission Detail - BCH6627
Tracking Number - 2368

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Current Status: Approved, Permanent Archive - 2011-03-11
Campus: Tampa
Submission Type: Change
Course Change Information (for course changes only): Change Course Title to "Molecular Basis of Disease" Change Credit Hours to 4 credits Course has changed from strictly didatic material to a course presented in a modular (4 Units) format as a combination of lecture, discussion, and presentation formats. The various units are supplemented with a number of “case studies” that reinforce the medically related aspects of the material. The course requires student participation plus additional hours of reading, writing, and research. There will be online discussions with other course participants
Comments: to grad council 12/6/10; GC approved 1/24/11; to USF System for concurrence 1/27/11; to SCNS 2/7/11. SCNS approved. Effective 3/11/11. posted in banner

Detail Information

  1. Date & Time Submitted: 2010-08-24
  2. Department: Medical Sciences
  3. College: MD
  4. Budget Account Number:
  5. Contact Person: Duane C. Eichler, Ph.D.
  6. Phone: 9749716
  7. Email:
  8. Prefix: BCH
  9. Number: 6627
  10. Full Title: Metabolic and Genetic Basis of Human Disease
  11. Credit Hours: 3
  12. Section Type: D - Discussion (Primarily)
  13. Is the course title variable?: N
  14. Is a permit required for registration?: Y
  15. Are the credit hours variable?: N
  16. Is this course repeatable?:
  17. If repeatable, how many times?: 0
  18. Abbreviated Title (30 characters maximum):
  19. Course Online?: C - Face-to-face (0% online)
  20. Percentage Online: 0
  21. Grading Option: R - Regular
  22. Prerequisites: GMS 6100 with an A or B grade
  23. Corequisites: Completion of a Bachelor's degree or its equivalent
  24. Course Description: The Molecular Basis of Disease (BCH 6627) course will provide students with an opportunity to learn about the research underlying our knowledge of disease mechanisms. It will be taught in a multi-disciplinary manner to promote an understanding of the m

  25. Please briefly explain why it is necessary and/or desirable to add this course: Replacing Selected Topics with Permanent number; already listed in program
  26. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service? This Ph.D. graduate-level course is directed towards students who have an interest in the medical research or who are focused on future research related to health careers. Students interested in pursuing a medical or health-related career require familiarity with the diverse aspects of biomedical sciences that includes the essentials of molecular biology, biochemistry, immunology and neuroscience. This course is also intended to be the entry "Flagship" core course for Medical Sciences Ph.D. students selecting a concentration in Molecular Medicine.
  27. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times? Yes, 1 time
  28. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.) Faculty who teach in this course have conducted funded research, have graduate students (research assistants), carry out medical or health-related research, and have a strong backgroud in biomedical sciences that includes the essentials one of the following areas: molecular biology, biochemistry, immunology or neuroscience.
  29. Objectives: The overall objectives of Molecular Basis of Disease are to provide current or aspiring PhD students with a fundamental understanding of biological and genetic principles basic to pathophysiological processes; to explain the molecular mechanisms that underlie the cellular aberrations in clinical disorders; and to understand, synthesize, and incorporate the fundamental principles learned as they apply to medical research.
  30. Learning Outcomes: Upon completion of this course, students should be able to:

    1. Describe causes of selected disorders in molecular and cellular terms.

    2. Compare and contrast molecular mechanisms of different disorders and how they impair normal cellular processes.

    3. Examine current treatment strategies for selected disorders, their rationale, and how they are effective.

    4. Evaluate current experimental procedures used in disease diagnosis, research and treatment.

  31. Major Topics: Cell signalling disorders

    Metabolic Disorders

    Neurologic Disorders

    Immunologic and Infection Disorders

  32. Textbooks: None
  33. Course Readings, Online Resources, and Other Purchases: Specific reading assignments will be required for the course and will be assigned for each Unit. Reading assignments are the primary means by which each student will acquire the core content of the course. It is essential that students complete the reading assignments for comprehension early in each Unit.
  34. Student Expectations/Requirements and Grading Policy: A student's course grade will be determined by the weighting of their percent score for the Section Discussions, Unit Presentations, and Unit Exams as follows.

    Discussion 20% - (5% for each module discussion)

    Unit Exams: 48% - (12% for each module exam)

    Unit Presentations: 32% - (8% for each Module Report)

  35. Assignments, Exams and Tests: Reading Assignments:

    Specific reading assignments will be required for the course and will be assigned for each Unit. Reading assignments are the primary means by which each student will acquire the core content of the course. It is essential that students complete the reading assignments for comprehension early in each Unit.

    Class Discussions:

    For each Unit, class discussion topics will be introduced. All students are expected to participate in the class discussions. In addition, each student is expected to post a discussion topic, and to respond to at least two other students discussion posts, before the start of the next Unit. Each student post should be at least one paragraph supported by referenced resources.

    Unit Presentation:

    Students will be required to present an original presentation related to assigned topic or paper. Grades received for Unit Presentations (Appendix C) will be included in the final course grade calculation. A Unit Presentation will follow the format (template) given in the Appendix C under Unit Presentation. The presentation shall be no longer than 10 minutes, allowing additional time for questions and discussion. The Unit Presentation must be posted on the course Blackboard site two days in advance of the presentation so that other students and faculty will have access to presentation in advance. Extensions are only given due to extreme circumstances, or emergencies. Students are required to provide appropriate documentation, which will be determined acceptable by the instructor BEFORE being granted an extension. See Appendix C for the PowerPoint presentation template.


    A Unit exam will consist of short answer and/or essay type questions. Grades will be posted in the grade book for each Unit exam and included in the calculation of the final course grade. The Unit exam will be comprehensive of all material covered for that unit. The day and time for the exam will be identified in the course schedule.

  36. Attendance Policy: Course Attendance at First Class Meeting – Policy for Graduate Students: For structured courses, 6000 and above, the College/Campus Dean will set the first-day class attendance requirement. Check with the College for specific information. This policy is not applicable to courses in the following categories: Educational Outreach, Open University (TV), FEEDS Program, Community Experiential Learning (CEL), Cooperative Education Training, and courses that do not have regularly scheduled meeting days/times (such as, directed reading/research or study, individual research, thesis, dissertation, internship, practica, etc.). Students are responsible for dropping undesired courses in these categories by the 5th day of classes to avoid fee liability and academic penalty. (See USF Regulation – Registration - 4.0101,

    Attendance Policy for the Observance of Religious Days by Students: In accordance with Sections 1006.53 and 1001.74(10)(g) Florida Statutes and Board of Governors Regulation 6C-6.0115, the University of South Florida (University/USF) has established the following policy regarding religious observances: (

    In the event of an emergency, it may be necessary for USF to suspend normal operations. During this time, USF may opt to continue delivery of instruction through methods that include but are not limited to: Blackboard, Elluminate, Skype, and email messaging and/or an alternate schedule. It’s the responsibility of the student to monitor Blackboard site for each class for course specific communication, and the main USF, College, and department websites, emails, and MoBull messages for important general information.

  37. Policy on Make-up Work: Make-up work will only be given due to extreme circumstances or emergencies. Students will be required to provide appropriate documentation, which will be determined acceptable by the course director before being assigned make-up work.See
  38. Program This Course Supports: Medical Sciences Ph.D. with Concentration in Molecular Medicine
  39. Course Concurrence Information: Medical Science Ph.D. program

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