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Graduate Course Proposal Form Submission Detail - BME6108

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Current Status: Approved, Permanent Archive - 2005-05-27
Submission Type:
Course Change Information (for course changes only):

  1. Department and Contact Information

    Tracking Number Date & Time Submitted
    1864 2005-04-07
    Department College Budget Account Number
    Chemical Engineering EN 2107 000 00
    Contact Person Phone Email
    Bill Lee 9742136

  2. Course Information

    Prefix Number Full Title
    BME 6108 Biomaterials II: Biocompatibility

    Is the course title variable? N
    Is a permit required for registration? N
    Are the credit hours variable? N
    Is this course repeatable?
    If repeatable, how many times? 0

    Credit Hours Section Type Grading Option
    3 C - Class Lecture (Primarily) R - Regular
    Abbreviated Title (30 characters maximum)
    Biomaterials II
    Course Online? Percentage Online


    Graduate standing in engineering or CI



    Course Description

    Biocompatibility issues of biomaterials, including inflammation, wound healing, foreign body response, toxicity, blood coagulation, tumorigenesis, infection, and related issues including testing. Degradation of materials in the biological environment.

  3. Justification

    A. Please briefly explain why it is necessary and/or desirable to add this course.

    This is a part of the restructuring/expansion of the previous single semester course "Biomaterials and Biocompatbility" (BME 6107) proposed to support the growing program in biomedical engineering (BME), including the recently approved PhD degree. This w

    B. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service?

    Again, the two-course sequence will provide an in depth treatment of this core BME subject area. This will better prepare students who have biomaterials issues in their BME research (a significant percentage of research projects). The sequence itself is an elective, although most BME students have selected the existing one semester course, a course that has also been selected by other engineering majors and life science majors.

    C. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times?

    The single semester version was offered almost annually from 1994 - 2003. In 2004, the "new" 2-course sequence was offered, with semester I being the existing class (BME 6107) and semester II offered under ECH 6931 (Selected Topics).

    D. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.)

    The instructor should have a PhD in biomedical engineering, chemical engineering, materials science/engineering, or a related field.

  4. Other Course Information

    A. Objectives

    This class will focus on biomaterial/biological tissue and fluid interactions, including: 1) the various body responses (inflammation, wound healing, foreign body response, immunological response, toxicity and hypersensitivty, blood coagulation, tumorigenesis, and material-related infection. Also, relevant testing techniques (in vitro, in vivo, blood testing, etc.) will be addressed. Degratadion of the materials in the biological environment will be explored. Finally, the regulatory and other product development aspects of biocompatibility will be discussed in detail.

    B. Learning Outcomes

    Students will be able to: 1) appreciate the complexity of poossible body responses to the introduction of a foreign material; 2) understand that the design challenge of producing a "biocompatible" or "blood compatible" material is very formidable; 3) appreciate the multidisciplinary aspects of biomaterials; 4) describe the current theories of biocompatibility, tumorigeneses, and related body-responses; 5) appreciate the various biocompatibility testing protocols and the need to reduce animal testing; 6) appreciate the complexity and sequential nature of the regulatory process, and 7) know how to locate information related to biocompatibility.

    C. Major Topics

    1) Degradation of materials in the biological environment (chemical and mechanical); 2) Host reactions to biomaterials: 2a) inflammation; 2b) wound healing; 2c) foreign body response; 2d) immunology; 2e) toxicity; 2f) hypersensitivity; 2g) blood colagulation; 2f) tumorigenesis; 2g) infection issues; 3) testing of biomaterials: 3a) in vivo assessment; 3b) in vitro assessment; 3c) blood/materials interaction testing; 4) the regulatory process and impact on biocompatibilty issues of product development.

    D. Textbooks

    Biomaterials science by B. Ratner, A. Hoffman, F. Schoen, and J. Lemons. Also, extensive handouts would supplement the text.

    E. Course Readings, Online Resources, and Other Purchases

    F. Student Expectations/Requirements and Grading Policy

    G. Assignments, Exams and Tests

    H. Attendance Policy

    I. Policy on Make-up Work

    J. Program This Course Supports

  5. Course Concurrence Information

- if you have questions about any of these fields, please contact or