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Graduate Course Proposal Form Submission Detail - GMS6016
Tracking Number - 1622

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Current Status: Approved, Permanent Archive - 2008-01-03
Submission Type:
Course Change Information (for course changes only):

Detail Information

  1. Date & Time Submitted: 2007-11-12
  2. Department: Graduate Affairs
  3. College: MD
  4. Budget Account Number: 610601-000000
  5. Contact Person: Michael J. Barber, D.Phil.
  6. Phone: 9749702
  7. Email:
  8. Prefix: GMS
  9. Number: 6016
  10. Full Title: Basic Medical Genetics
  11. Credit Hours: 3
  12. Section Type: C - Class Lecture (Primarily)
  13. Is the course title variable?: N
  14. Is a permit required for registration?: Y
  15. Are the credit hours variable?: N
  16. Is this course repeatable?:
  17. If repeatable, how many times?: 0
  18. Abbreviated Title (30 characters maximum): Basic Medical Genetics
  19. Course Online?: -
  20. Percentage Online:
  21. Grading Option: R - Regular
  22. Prerequisites: 1 yr Biology; 1 yr Chemistry
  23. Corequisites: None
  24. Course Description: The course examines fundamental aspects of genetics critical to understanding the mechanisms and inheritance patterns of genetic diseases relevant to human health including clinical, biochemical and molecular genetics, cytogenetics and genetic counseling.

  25. Please briefly explain why it is necessary and/or desirable to add this course: This course is one of the eleven courses that comprise the College of Medicine's new Master's concentration in Health Sciences which will be a fully on-line graduate program directed at students who are interested in careers in the health or allied health
  26. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service? Health-related careers continue to have a very strong demand by students and this course will fill a critical gap in our educational program, both by providing the first course in medical genetics and by providing access to medically-related courses to students who cannot attend the conventional lecture courses. The course could also serve graduate students in other schools and colleges who have an interest in medical genetics, such as Physical Therapy, Pharmacy and Arts and Sciences.
  27. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times? No
  28. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.) The minimum qualifications to teach this course are a Ph.D. degree in Molecular Genetics or a related discipline and several years teaching experience at the graduate level. The current instructors have over 25 years of experience teaching this material at the graduate level.
  29. Objectives: The course develops a broad and thorough understanding of medical genetics. It features a number of areas including clinical genetics, biochemical genetics, cytogenetics, molecular genetics and genetic counseling. Understanding the principles that govern the topics of medical genetics, genomes and genes together with the various modes of genetic inheritance and genetic variation and an understanding of how these processes are altered by disease are critical to modern medical science.
  30. Learning Outcomes: At the completion of this course, students will be able to describe how genetic factors predispose to mendelian and multifactorial diseases and the implications of such predispositions for disease diagnosis, treatment and prevention. Explain the clinical manifestations of common mendelian diseases. Identify the clinical features of common chromosomal aneuploidies and the signs generally associated with other kinds of chromosomal imbalance. Describe how constitutional and acquired genetic alterations can lead to the development of malignant neoplasms and how identification of these changes can be used in the diagnosis, management and prevention of malignancy. Explain how knowledge of a patient's genotype can be used to develop a more effective approach to health maintenance, disease diagnosis, and treatment for that particular individual. Understand the procedures that are generally employed for prenatal genetic diagnosis and the indications for such testing together with the advantages, limitations, and disadvantages of pre-symptomatic testing for genetic disease. Explain the existence of and justification for screening programs to detect genetic disease, and the difference between screening and more definitive testing and describe the differences in goals and approach among screening programs for genetic diseases in newborn infants, pregnant women, and other adults. Explain the conventional approaches to treatment of genetic diseases and the general status of gene-based therapies and what exposures are likely to be teratogenic in humans and how such exposures can be prevented.
  31. Major Topics: This course emphasizes the principles of medical genetics including the basic genetic mechanims, the structure and organization of DNA, chromosomes and the various mechanisms of inheritance; the genetics of metabolic disorders and cancer genetics; genetic considerations in hematologic and musculoskeletal disorders and neurologic diseases; the genetics of cardiopulmonary, hepatic, renal, gastrointestinal and gender diffferentiation disorders; population genetics and the relevance to modern molecular medicine.
  32. Textbooks: The required course textbooks are:

    “Elsevier’s Integrated Genetics” (Adkinson, L. & Brown, M.D.) Elsevier, 2007

    ISBN-13: 978-0-323-04329-1

    “Thompson & Thompson Genetics in Medicine” (Nussbaum, R.L., McInnes, R.R.& Willard, H.F.) 7th Ed. Saunders, 2007

    ISBN-13: 1416030808

  33. Course Readings, Online Resources, and Other Purchases:
  34. Student Expectations/Requirements and Grading Policy:
  35. Assignments, Exams and Tests:
  36. Attendance Policy:
  37. Policy on Make-up Work:
  38. Program This Course Supports:
  39. Course Concurrence Information:

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