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Graduate Course Proposal Form Submission Detail - GMS6XXX

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Current Status: Approved, Permanent Archive - 2009-06-03
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  1. Department and Contact Information

    Tracking Number Date & Time Submitted
    1546 2009-02-24
     
    Department College Budget Account Number
    Graduate Affairs MD 6108
     
    Contact Person Phone Email
    Michael J. Barber, D.Phil. 9749908 mbarber@health.usf.edu

  2. Course Information

    Prefix Number Full Title
    GMS 6XXX Integrated Clinical Neurobiology

    Is the course title variable? N
    Is a permit required for registration? Y
    Are the credit hours variable? N
    Is this course repeatable?
    If repeatable, how many times? 0

    Credit Hours Section Type Grading Option
    3 C - Class Lecture (Primarily) R - Regular
     
    Abbreviated Title (30 characters maximum)
    Clinical Neurobiology
     
    Course Online? Percentage Online
    -

    Prerequisites

    None

    Corequisites

    None

    Course Description

    The course introduces the principles of neurology and the role of neurotransmitters in cellular function and communication between cell types and focuses on gastrointestinal health in relationship to the immune system and neurotransmitter function


  3. Justification

    A. Please briefly explain why it is necessary and/or desirable to add this course.

    This course is a component of the new concentration in Metabolic and Nutritional Medicine that is part of the Medical Sciences Master's Program in the College of Medicine. The course is deigned to develop clinician and health-care professional expertize i

    B. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service?

    This course is valuable to practicing clinicians and other health-care professionals who are interested in further developing their patient care skills in the filed of neurobiology and the associated diseases. Previous presentations of portions of the course material have attracted an enrollment of over 200 participants and this enrollment is expected to be maintained.

    C. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times?

    This course has not been previously offered as a selected topic in the College of Medicine. However, portions of the material have been previously offered as part of a CME program for experience clinicians.

    D. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.)

    All of the faculty involved in this course are experienced M.D. or Ph.D. faculty with extensive experience in teaching medical and graduate students and clinical residents.


  4. Other Course Information

    A. Objectives

    The major course objectives include:

    • Discussing new therapeutic strategies for multiple sclerosis, stroke recovery, Parkinson’s disease, ALS, and Alzheimer’s disease

    • Understanding and evaluate the energy producing ability of the mitochondria and their role in revitalizing neurological tissue

    • Discussing factors associated with intestinal permeability

    • Identifying the consequences of inflammation on the neurological system

    • Examining the role endocytic receptors, scavenger receptors and the receptor for advanced glycation end products (RAGE) have on the inflammatory response

    • Understanding the importance of the gastrointestinal tract’s role in the immune function

    • Identifying the causes of microbial imbalances on or with in the body (dysbiosis) and develop techniques to repair gut health

    • Critically and adequately evaluating and treating patients for weight loss using a Regenerative Medicine approach

    • Understanding the crucial role that neurotransmitters have in the body and how they impact various organ systems

    • Identifying the symptoms and diseases associated with food allergy and intolerance

    • Discussing the symptoms and be able to diagnosis and treat chronic yeast infections

    • Examining the many reasons why patients have a difficult time losing weight and maintaining weight loss

    • Developing individualized treatment plans for affecting weight loss

    • Understanding how to diagnose and treat the causes of most major diseases of the GI tract

    • Demonstrating a comprehensive understanding of the relationship between the GI tract and neurotransmitter function

    B. Learning Outcomes

    Following the successful completion of this course, students will be able to:

    • Discuss new therapeutic strategies for multiple sclerosis, stroke recovery, Parkinson’s disease, ALS, and Alzheimer’s disease

    • Understand and evaluate the energy producing ability of the mitochondria and their role in revitalizing neurological tissue

    • Discuss factors associated with intestinal permeability

    • Identify the consequences of inflammation on the neurological system

    • Examine the role endocytic receptors, scavenger receptors and the receptor for advanced glycation end products (RAGE) have on the inflammatory response

    • Understand the importance of the gastrointestinal tract’s role in the immune function

    • Identify the causes of microbial imbalances on or with in the body (dysbiosis) and develop techniques to repair gut health

    • Critically and adequately evaluate and treat patients for weight loss using a Regenerative Medicine approach

    • Understand the crucial role that neurotransmitters have in the body and how they impact various organ systems

    • Identify the symptoms and diseases associated with food allergy and intolerance

    • Discuss the symptoms and be able to diagnosis and treat chronic yeast infections

    • Examine the many reasons why patients have a difficult time losing weight and maintaining weight loss

    • Develop individualized treatment plans for affecting weight loss

    • Understand how to diagnose and treat the causes of most major diseases of the GI tract

    • Demonstrate a comprehensive understanding of the relationship between the GI tract and neurotransmitter function

    C. Major Topics

    Major course topics include:

    The neurobiology of mood and cognition

    Discussing statistics on the incidence of neurobehavioral disorders

    Identifying physiological conditions associated with neurotransmitter imbalance

    Identifying the dominant neurotransmitters involved in behavior modification

    Developing a neuro-behavioral symptom checklist

    Comparing and contrasting various brain imaging methods

    Discussing the role(s) of dopamine and norepinephrine in the CNS

    Identifying common symptoms of dopamine imbalance

    Describing the regulation of dopamine synthesis

    Examining the neurobiology of mood disorders

    Discussing the role(s) of serotonin in the CNS

    Identifying common symptoms of serotonin imbalance

    Describing the regulation of serotonin synthesis and the function of tryptophan hydroxylase

    Reviewing the roles of GABA and glutamate in the CNS

    Identifying the core symptoms of glutamate imbalance and disease states

    Comparing and contrasting brain imaging techniques in assessing glutamate imbalance

    Examining the neurobiology of acetylcholine and dementia

    Reviewing the role of acetylcholine in the CNS

    Comparing and contrasting the pathways for acetylcholine synthesis and degradation

    Examining the risk factors for Alzheimer’s disease

    Discussing the factors regulating amyloid processing

    Reviewing the roles of melatonin and GABA in sleep

    Comparing and contrasting the properties of normal and disturbed sleep function

    Examining the sleep-wake cycle

    Discussing improving diagnostic and therapeutic decisions in common GI complaints

    Discussing approaches to optimizing gut function

    Describing modulators of gut inflammation, including genes and the GI environment

    Reviewing neuroendocrine regulation (the brain-gut axis)

    Discussing host-flora interactions and the metabolic functions of GI bacteria

    Discussing the post-natal development of mucosal immunity

    Examining the roles of TH-1 and TH-2 in modulating GI inflammation

    Reviewing cytokine classification

    Discussing integrative approaches to the diagnosis and treatment of autoimmune diseases

    Identifying the range of autoimmune diseases, such as Addison’s and Graves’ diseases

    Discussing the prevalence of common autoimmune diseases

    Reviewing autoimmune activation events

    Comparing and contrasting the symptoms of yeast infection in females and males

    Identifying common symptoms of yeast infections in children and adolescents

    Identifying signs of intestinal dysfunction and poor digestion

    Identifying signs of optimal digestion

    Reviewing the impact of various nutrients and the gut

    Discussing the basic components and function of the nervous system

    Reviewing neuroendocrine anatomy

    Examining selected case studies that focus on depression

    D. Textbooks

    Smith, P., “Demystifying Weight Loss”. Traverse City, MI: Healthy Living Books, 2004.

    Perlmutter, D. “The Better Brain Book”. New York: Penguin Group, Inc., 2004.

    Siegel, G., (Ed). Basic Neurochemistry. (7th Ed). New York: Academic Press, 2006.

    E. Course Readings, Online Resources, and Other Purchases

    F. Student Expectations/Requirements and Grading Policy

    G. Assignments, Exams and Tests

    H. Attendance Policy

    I. Policy on Make-up Work

    J. Program This Course Supports


  5. Course Concurrence Information



- if you have questions about any of these fields, please contact chinescobb@grad.usf.edu or joe@grad.usf.edu.