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Graduate Course Proposal Form Submission Detail - GMS6XXX
Tracking Number - 1546
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Approved, Permanent Archive - 2009-06-03
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Detail Information
- Date & Time Submitted: 2009-02-24
- Department: Graduate Affairs
- College: MD
- Budget Account Number: 6108
- Contact Person: Michael J. Barber, D.Phil.
- Phone: 9749908
- Email: mbarber@health.usf.edu
- Prefix: GMS
- Number: 6XXX
- Full Title: Integrated Clinical Neurobiology
- Credit Hours: 3
- Section Type: C -
Class Lecture (Primarily)
- Is the course title variable?: N
- Is a permit required for registration?: Y
- Are the credit hours variable?: N
- Is this course repeatable?:
- If repeatable, how many times?: 0
- Abbreviated Title (30 characters maximum): Clinical Neurobiology
- Course Online?: -
- Percentage Online:
- Grading Option:
R - Regular
- Prerequisites: None
- Corequisites: None
- Course Description: The course introduces the principles of neurology and the role of neurotransmitters in cellular function and communication between cell types and focuses on gastrointestinal health in relationship to the immune system and neurotransmitter function
- Please briefly explain why it is necessary and/or desirable to add this course: This course is a component of the new concentration in Metabolic and Nutritional Medicine that is part of the Medical Sciences Master's Program in the College of Medicine. The course is deigned to develop clinician and health-care professional expertize i
- What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service? This course is valuable to practicing clinicians and other health-care professionals who are interested in further developing their patient care skills in the filed of neurobiology and the associated diseases. Previous presentations of portions of the course material have attracted an enrollment of over 200 participants and this enrollment is expected to be maintained.
- Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times? This course has not been previously offered as a selected topic in the College of Medicine. However, portions of the material have been previously offered as part of a CME program for experience clinicians.
- What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.) All of the faculty involved in this course are experienced M.D. or Ph.D. faculty with extensive experience in teaching medical and graduate students and clinical residents.
- Objectives: The major course objectives include:
• Discussing new therapeutic strategies for multiple sclerosis, stroke recovery, Parkinson’s disease, ALS, and Alzheimer’s disease
• Understanding and evaluate the energy producing ability of the mitochondria and their role in revitalizing neurological tissue
• Discussing factors associated with intestinal permeability
• Identifying the consequences of inflammation on the neurological system
• Examining the role endocytic receptors, scavenger receptors and the receptor for advanced glycation end products (RAGE) have on the inflammatory response
• Understanding the importance of the gastrointestinal tract’s role in the immune function
• Identifying the causes of microbial imbalances on or with in the body (dysbiosis) and develop techniques to repair gut health
• Critically and adequately evaluating and treating patients for weight loss using a Regenerative Medicine approach
• Understanding the crucial role that neurotransmitters have in the body and how they impact various organ systems
• Identifying the symptoms and diseases associated with food allergy and intolerance
• Discussing the symptoms and be able to diagnosis and treat chronic yeast infections
• Examining the many reasons why patients have a difficult time losing weight and maintaining weight loss
• Developing individualized treatment plans for affecting weight loss
• Understanding how to diagnose and treat the causes of most major diseases of the GI tract
• Demonstrating a comprehensive understanding of the relationship between the GI tract and neurotransmitter function
- Learning Outcomes: Following the successful completion of this course, students will be able to:
• Discuss new therapeutic strategies for multiple sclerosis, stroke recovery, Parkinson’s disease, ALS, and Alzheimer’s disease
• Understand and evaluate the energy producing ability of the mitochondria and their role in revitalizing neurological tissue
• Discuss factors associated with intestinal permeability
• Identify the consequences of inflammation on the neurological system
• Examine the role endocytic receptors, scavenger receptors and the receptor for advanced glycation end products (RAGE) have on the inflammatory response
• Understand the importance of the gastrointestinal tract’s role in the immune function
• Identify the causes of microbial imbalances on or with in the body (dysbiosis) and develop techniques to repair gut health
• Critically and adequately evaluate and treat patients for weight loss using a Regenerative Medicine approach
• Understand the crucial role that neurotransmitters have in the body and how they impact various organ systems
• Identify the symptoms and diseases associated with food allergy and intolerance
• Discuss the symptoms and be able to diagnosis and treat chronic yeast infections
• Examine the many reasons why patients have a difficult time losing weight and maintaining weight loss
• Develop individualized treatment plans for affecting weight loss
• Understand how to diagnose and treat the causes of most major diseases of the GI tract
• Demonstrate a comprehensive understanding of the relationship between the GI tract and neurotransmitter function
- Major Topics: Major course topics include:
The neurobiology of mood and cognition
Discussing statistics on the incidence of neurobehavioral disorders
Identifying physiological conditions associated with neurotransmitter imbalance
Identifying the dominant neurotransmitters involved in behavior modification
Developing a neuro-behavioral symptom checklist
Comparing and contrasting various brain imaging methods
Discussing the role(s) of dopamine and norepinephrine in the CNS
Identifying common symptoms of dopamine imbalance
Describing the regulation of dopamine synthesis
Examining the neurobiology of mood disorders
Discussing the role(s) of serotonin in the CNS
Identifying common symptoms of serotonin imbalance
Describing the regulation of serotonin synthesis and the function of tryptophan hydroxylase
Reviewing the roles of GABA and glutamate in the CNS
Identifying the core symptoms of glutamate imbalance and disease states
Comparing and contrasting brain imaging techniques in assessing glutamate imbalance
Examining the neurobiology of acetylcholine and dementia
Reviewing the role of acetylcholine in the CNS
Comparing and contrasting the pathways for acetylcholine synthesis and degradation
Examining the risk factors for Alzheimer’s disease
Discussing the factors regulating amyloid processing
Reviewing the roles of melatonin and GABA in sleep
Comparing and contrasting the properties of normal and disturbed sleep function
Examining the sleep-wake cycle
Discussing improving diagnostic and therapeutic decisions in common GI complaints
Discussing approaches to optimizing gut function
Describing modulators of gut inflammation, including genes and the GI environment
Reviewing neuroendocrine regulation (the brain-gut axis)
Discussing host-flora interactions and the metabolic functions of GI bacteria
Discussing the post-natal development of mucosal immunity
Examining the roles of TH-1 and TH-2 in modulating GI inflammation
Reviewing cytokine classification
Discussing integrative approaches to the diagnosis and treatment of autoimmune diseases
Identifying the range of autoimmune diseases, such as Addison’s and Graves’ diseases
Discussing the prevalence of common autoimmune diseases
Reviewing autoimmune activation events
Comparing and contrasting the symptoms of yeast infection in females and males
Identifying common symptoms of yeast infections in children and adolescents
Identifying signs of intestinal dysfunction and poor digestion
Identifying signs of optimal digestion
Reviewing the impact of various nutrients and the gut
Discussing the basic components and function of the nervous system
Reviewing neuroendocrine anatomy
Examining selected case studies that focus on depression
- Textbooks: Smith, P., “Demystifying Weight Loss”. Traverse City, MI: Healthy Living Books, 2004.
Perlmutter, D. “The Better Brain Book”. New York: Penguin Group, Inc., 2004.
Siegel, G., (Ed). Basic Neurochemistry. (7th Ed). New York: Academic Press, 2006.
- Course Readings, Online Resources, and Other Purchases:
- Student Expectations/Requirements and Grading Policy:
- Assignments, Exams and Tests:
- Attendance Policy:
- Policy on Make-up Work:
- Program This Course Supports:
- Course Concurrence Information:
- if you have questions about any of these fields, please contact chinescobb@grad.usf.edu or joe@grad.usf.edu.