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Graduate Course Proposal Form Submission Detail - GMS6XXX

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Current Status: Approved, Permanent Archive - 2009-06-03
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  1. Department and Contact Information

    Tracking Number Date & Time Submitted
    1545 2009-02-24
     
    Department College Budget Account Number
    Graduate Affairs MD 6108
     
    Contact Person Phone Email
    Michael J. Barber, D.Phil. 9749908 mbarber@health.usf.edu

  2. Course Information

    Prefix Number Full Title
    GMS 6XXX Nutrition and Metabolism

    Is the course title variable? N
    Is a permit required for registration? Y
    Are the credit hours variable? N
    Is this course repeatable?
    If repeatable, how many times? 0

    Credit Hours Section Type Grading Option
    3 C - Class Lecture (Primarily) R - Regular
     
    Abbreviated Title (30 characters maximum)
    Nutrition and Metabolism
     
    Course Online? Percentage Online
    -

    Prerequisites

    None

    Corequisites

    None

    Course Description

    The course provides a discussion of the experimental analysis of human nutrition and the methods used in detoxification of exogenous toxins together with a critical analysis of the roles of fatty acid and amino acid metabolism in organ homeostasis.


  3. Justification

    A. Please briefly explain why it is necessary and/or desirable to add this course.

    This course is a component of the new concentration in Metabolic and Nutritional Medicine that is part of the Medical Sciences Master's Program in the College of Medicine. The course is deigned to develop clinician and health-care professional expertize i

    B. What is the need or demand for this course? (Indicate if this course is part of a required sequence in the major.) What other programs would this course service?

    This course is a component of the new concentration in Metabolic and Nutritional Medicine that is part of the Medical Sciences Master's Program in the College of Medicine. The course is deigned to develop clinician and health-care professional expertize in the area of human nutrition and metabolism with particular emphasis on the function of the various metabolic pathways and associated diseases.

    C. Has this course been offered as Selected Topics/Experimental Topics course? If yes, how many times?

    This course has not been previously offered as a selected topic in the College of Medicine. However, portions of the material have been previously offered as part of a CME program for experienced clinicians.

    D. What qualifications for training and/or experience are necessary to teach this course? (List minimum qualifications for the instructor.)

    All of the faculty involved in this course are experienced M.D. or Ph.D. faculty with extensive experience in teaching medical and graduate students and clinical residents.


  4. Other Course Information

    A. Objectives

    The major course objectives include:

    • Understanding the role of nutrition in maintaining optimal health as the patient ages

    • Reviewing the functions and regulation of the various catabolic and anabolic pathways that comprise intermediary metabolism.

    • Discussing phase I and phase II detoxification systems and the consequences of the body’s inability to detoxify

    • Identifying nutritional depletions caused by medications

    • Understanding the oxidative perspective on newer treatments for autism

    • Understanding the relationships among the biotransformation enzyme systems

    • Identifying the common warning signs indicating that toxicity may be a factor for the patient

    • Understanding the roles of physical, psychological, and spiritual health in Regenerative and Medicine

    • Critically evaluating the latest information concerning bi-function detoxification processes and the capacity of specific nutrients to normalize phase I and phase II detoxification

    • Identifying essential, conditionally essential and non-essential amino acids and symptoms of amino acid deficiencies

    • Discussing new treatment plans for osteoporosis

    • Reviewing the pharmaceutical inhibitors of Phase 1 cytochrome P450 enzymes

    • Identifying treatment modalities for the dietary and nutritional support of detoxification

    • Discussing new treatments for ADD/ADHD

    • Identifying the risk factors for osteoporosis

    • Discussing the metallothioneins and genetic polymorphisms

    • Understanding the function of fatty acids in the body

    • Evaluating treatments for amino acid deficiencies

    • Discussing therapeutic strategies for a regenerative treatment of cancer

    • Understanding disease processes that have amino acid deficiencies as an antecedent

    • Identifying the diseases that can be treated with fatty acid replacement

    • Understanding that fatty acid intake can change the amount of medication that a patient may need

    • Instructing clinicians and patients in new pain control options used in Regenerative Medicine

    • Understanding fatty acids may have profound effects on the network of inflammatory mediators altering prostanoid synthesis, PPAR activity and the response to cytokines

    B. Learning Outcomes

    Following the successful completion of this course, students will be able to:

    • Understand the role of nutrition in maintaining optimal health as the patient ages

    • Review the functions and regulation of the various catabolic and anabolic pathways that comprise intermediary metabolism.

    • Discuss phase I and phase II detoxification systems and the consequences of the body’s inability to detoxify

    • Identify nutritional depletions caused by medications

    • Understand the oxidative perspective on newer treatments for autism

    • Understand the relationships among the biotransformation enzyme systems

    • Identify the common warning signs indicating that toxicity may be a factor for the patient

    • Understand the roles of physical, psychological, and spiritual health in Regenerative and Medicine

    • Critically evaluate the latest information concerning bi-function detoxification processes and the capacity of specific nutrients to normalize phase I and phase II detoxification

    • Identify essential, conditionally essential and non-essential amino acids and symptoms of amino acid deficiencies

    • Discuss new treatment plans for osteoporosis

    • Review the pharmaceutical inhibitors of Phase 1 cytochrome P450 enzymes

    • Identify treatment modalities for the dietary and nutritional support of detoxification

    • Discuss new treatments for ADD/ADHD

    • Identify the risk factors for osteoporosis

    • Discuss the metallothioneins and genetic polymorphisms

    • Understand the function of fatty acids in the body

    • Be able to suggest treatments for amino acid deficiencies

    • Discuss therapeutic strategies for a regenerative treatment of cancer

    • Understand disease processes that have amino acid deficiencies as an antecedent

    • Identify the diseases that can be treated with fatty acid replacement

    • Understand that fatty acid intake can change the amount of medication that a patient may need

    • Instruct clinicians and patients in new pain control options used in Regenerative Medicine

    • Understand fatty acids may have profound effects on the network of inflammatory mediators altering prostanoid synthesis, PPAR activity and the response to cytokines

    C. Major Topics

    Major course topics include:

    Metabolic consequences of drug induced nutrient depletion

    Discussing the effects of female hormone medications, such as oral contraceptives, on specific nutrients

    Reviewing estrogen replacement therapy and its effects on vitamin and mineral depletion

    Examining the adverse effects of blood pressure regulators on vitamin and mineral depletion

    Discussing the impact of clinically used anti-hypertensive drugs on Coenzyme Q10-utilizing enzymes

    Discussing the historical and clinical features of gut dysfunction

    Reviewing the impact of upper gastrointestinal abnormalities and gut inflammation

    Examining the relationship between gut function and immune dysregulation

    Discussing the effects of cholesterol-lowering drugs on specific nutrients

    Reviewing the impact of anticonvulsants on vitamin availability

    Discussing the effects of anti-diabetic drugs on metabolism

    Critically examining the impact of selective serotonin reuptake inhibitors (SSRIs) on bone metabolism

    Examining the impact of anti-ulcer drugs on vitamin utilization

    Discussing the nutrition effects of proton pump inhibitors, anti-inflammatory drugs and corticosteroids

    Identifying nutritional concerns caused by antibiotics, antiviral agents, chemotherapy drugs, common pain medications, antacids and laxatives

    Discussing the advantages of optimizing metabolic performance with specific nutrients

    Examining the pathophysiological effects of stress on metabolism, obesity and sleep deprivation

    Discussing the effects of hormones on metabolism, the relationship between adrenal and toxicity and imbalances in hormone levels

    Critically evaluating various emerging natural therapies for stress-related health risks

    Discussing the relationship between thyroid function and metabolism and the effects of pesticides on thyroid function

    Reviewing the various functions of amino acids and the classification of essential/non-essential for metabolism

    Identifying amino acids not traditionally associated with protein formation and their functions

    Discussing the various symptoms associated with amino acid deficiencies

    Describing the various functions of the individual, 20 commonly-occurring amino acids, such as arginine, methionine and tyrosine, focusing on their metabolic roles, deficiency symptoms and common nutrient sources

    Discussing how amino acids are utilized in the treatment of various physiological disorders

    Reviewing the effects of various environmental toxins, such as organochlorine pesticides

    Examining the properties and metabolic effects of polychlorinated biphenyls

    Discussing the health effects of synthetic herbicides, such as glyphosate and triazine derivatives

    Reviewing the array of commonly encountered xenobiotics

    Discussing the occurrence of common toxins in food, such as acrylamide, and the environment

    Examining the toxicity of various metals

    Discussing the metabolic roles and properties of cytochrome P450 isozymes

    Reviewing phase II reactions and phase II substrate classes

    Examining the various causes of impaired detoxification

    Discussing functional toxicology and toxicogenomics, including clinical examples

    Examining various methods for assessing toxicity

    Reviewing the requirements, types and natural occurrence of various fatty acids

    Critically discussing the functions of fatty acids in the body

    Discussing the clinical manifestations of essential fatty acid deficiency

    Reviewing the essential fatty acid nomenclature.

    Identifying the various causes of fatty acid deficiencies

    Reviewing the incidence of osteoporosis in women

    Identifying the various risk factors for osteoporosis

    Discussing the effects of caffeine on calcium metabolism

    Reviewing important facts related to calcium supplementation including the effects of excess Ca2+ ingestion

    Identifying various calcium rich foods and factors that decrease calcium absorption

    Reviewing the production, properties, physiological requirements and isoforms of vitamin K

    Discussing the cofactor roles of vitamin K in enzyme function, blood coagulation and bone mineralization

    Reviewing the relationship between vitamin K and vascular health

    Discussing the relationship between antioxidants and cancer

    Discussing the use of vitamin C as chemotherapy

    Examining the use of lipoic acid/palladium complex as a dietary supplement

    Examining the clinical aspects of autism

    D. Textbooks

    McCandless, J. “Children with Starving Brains: A Medical Treatment Guide for Autism Spectrum Disorder”. Binstock, TX: Bramble Books, 2005.

    LaValle, J. “Cracking the Metabolic Code”. North Bergen, NJ: Basic Health Publications, Inc., 2004.

    Lieberman, S. “The Real Vitamin & Mineral Book”. New York: Penguin Group, 2007.

    Stipanuk, M. (Ed), “Biochemical, Physiological and Molecular Aspects of Human Nutrition”. Elsevier Saunders, 2006.

    E. Course Readings, Online Resources, and Other Purchases

    F. Student Expectations/Requirements and Grading Policy

    G. Assignments, Exams and Tests

    H. Attendance Policy

    I. Policy on Make-up Work

    J. Program This Course Supports


  5. Course Concurrence Information



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